Preheat Oven
Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper or lightly grease a loaf pan.
Prepare the Panade
In a large bowl, combine breadcrumbs and milk. Let sit for 5 minutes until softened.
Mix Meatloaf
Add ground beef, eggs, onion, garlic, ketchup, Worcestershire sauce, salt, pepper, thyme, and parsley to the bowl with the soaked breadcrumbs. Mix gently until just combined (do not overmix).
Shape the Loaf
Transfer the mixture to the prepared pan or shape into a loaf on the baking sheet.
Make the Glaze
In a small bowl, whisk together ketchup, brown sugar, and vinegar. Spread half of the glaze over the meatloaf.
Bake
Bake for 45 minutes. Remove from the oven, spread the remaining glaze on top, and return to bake for an additional 15–20 minutes, or until the internal temperature reaches 160°F (71°C).
Rest & Serve
Let the meatloaf rest for 10 minutes before slicing to allow juices to redistribute. Serve warm.